Size Reduction
It may be defined as the process of reducing the particle size of pharmaceutical substances or ingredients are known as size reduction.
In another ways, size reduction is the process of converting the coarse particles into fine particles by applying the mechanism like cutting, impact, attrition. and compression etc. This is typically done to achieve specific goals such as:
1. Improved Solubility: Smaller particles can dissolve more easily in liquids, which can be essential for medications to be absorbed by the body.
2. Enhanced Mixing: Reducing particle size can lead to more uniform mixing of ingredients in pharmaceutical formulations, ensuring that each dose contains the intended amount of active substance.
3. Easier Dispersion: Smaller particles are often easier to disperse in liquid or semi-solid formulations, making it simpler for patients to administer the medication.
4. Faster Dissolution: Size reduction can speed up the dissolution of tablets or capsules in the digestive tract, allowing for quicker onset of action. And many other applications.
Common methods of size reduction in pharmacy include milling, grinding, and micritization, which involve breaking down larger particles into smaller ones to achieve the desired particle size distribution for pharmaceutical formulations.
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